{"id":2748,"date":"2024-01-23T17:47:19","date_gmt":"2024-01-23T16:47:19","guid":{"rendered":"https:\/\/www.angelaserra.com\/salerno\/?p=2748"},"modified":"2024-01-23T17:47:19","modified_gmt":"2024-01-23T16:47:19","slug":"aifa-si-alla-somministrazione-e-rimborsabilita-di-un-nuovo-farmaco-per-il-tumore-del-seno-metastatico","status":"publish","type":"post","link":"https:\/\/www.angelaserra.com\/salerno\/2024\/01\/23\/aifa-si-alla-somministrazione-e-rimborsabilita-di-un-nuovo-farmaco-per-il-tumore-del-seno-metastatico\/","title":{"rendered":"Aifa: s\u00ec alla somministrazione e rimborsabilit\u00e0 di un nuovo farmaco per il tumore del seno metastatico"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\ud835\udc0b&#8217;\ud835\udc00\ud835\udc22\ud835\udc1f\ud835\udc1a, \ud835\udc00\ud835\udc20\ud835\udc1e\ud835\udc27\ud835\udc33\ud835\udc22\ud835\udc1a \ud835\udc08\ud835\udc2d\ud835\udc1a\ud835\udc25\ud835\udc22\ud835\udc1a\ud835\udc27\ud835\udc1a \ud835\udc1d\ud835\udc1e\ud835\udc25 \ud835\udc05\ud835\udc1a\ud835\udc2b\ud835\udc26\ud835\udc1a\ud835\udc1c\ud835\udc28, \ud835\udc21\ud835\udc1a \ud835\udc1d\ud835\udc1a\ud835\udc2d\ud835\udc28 \ud835\udc22\ud835\udc25 \ud835\udc2f\ud835\udc22\ud835\udc1a \ud835\udc25\ud835\udc22\ud835\udc1b\ud835\udc1e\ud835\udc2b\ud835\udc1a \ud835\udc1a\ud835\udc25\ud835\udc25\ud835\udc1a \ud835\udc2c\ud835\udc28\ud835\udc26\ud835\udc26\ud835\udc22\ud835\udc27\ud835\udc22\ud835\udc2c\ud835\udc2d\ud835\udc2b\ud835\udc1a\ud835\udc33\ud835\udc22\ud835\udc28\ud835\udc27\ud835\udc1e \ud835\udc1e \ud835\udc1a\ud835\udc25\ud835\udc25\ud835\udc1a \ud835\udc2b\ud835\udc22\ud835\udc26\ud835\udc1b\ud835\udc28\ud835\udc2b\ud835\udc2c\ud835\udc1a\ud835\udc1b\ud835\udc22\ud835\udc25\ud835\udc22\ud835\udc2d\u00e0 \ud835\udc1d\ud835\udc22 \ud835\udc2e\ud835\udc27 \ud835\udc27\ud835\udc2e\ud835\udc28\ud835\udc2f\ud835\udc28 \ud835\udc1f\ud835\udc1a\ud835\udc2b\ud835\udc26\ud835\udc1a\ud835\udc1c\ud835\udc28 per la seconda linea di trattamento (cio\u00e8 dopo una prima chemioterapia) del \ud835\udc2d\ud835\udc2e\ud835\udc26\ud835\udc28\ud835\udc2b\ud835\udc1e \ud835\udc1d\ud835\udc1e\ud835\udc25 \ud835\udc2c\ud835\udc1e\ud835\udc27\ud835\udc28 \ud835\udc26\ud835\udc1e\ud835\udc2d\ud835\udc1a\ud835\udc2c\ud835\udc2d\ud835\udc1a\ud835\udc2d\ud835\udc22\ud835\udc1c\ud835\udc28.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Denominato trastuzumab-deruxtecan, questo farmaco chemioterapico agisce in combinazione con un anticorpo monoclonale: \ud835\udc22\ud835\udc27 \ud835\udc29\ud835\udc1a\ud835\udc2b\ud835\udc28\ud835\udc25\ud835\udc1e \ud835\udc26\ud835\udc28\ud835\udc25\ud835\udc2d\ud835\udc28 \ud835\udc2c\ud835\udc1e\ud835\udc26\ud835\udc29\ud835\udc25\ud835\udc22\ud835\udc1c\ud835\udc22, \ud835\udc2b\ud835\udc22\ud835\udc1e\ud835\udc2c\ud835\udc1c\ud835\udc1e \ud835\udc1a\ud835\udc1d \ud835\udc1a\ud835\udc2b\ud835\udc2b\ud835\udc22\ud835\udc2f\ud835\udc1a\ud835\udc2b\ud835\udc1e \ud835\udc1a\ud835\udc25\ud835\udc25\u2019\ud835\udc22\ud835\udc27\ud835\udc2d\ud835\udc1e\ud835\udc2b\ud835\udc27\ud835\udc28 \ud835\udc1d\ud835\udc1e\ud835\udc25\ud835\udc25\ud835\udc1e \ud835\udc1c\ud835\udc1e\ud835\udc25\ud835\udc25\ud835\udc2e\ud835\udc25\ud835\udc1e \ud835\udc1e \ud835\udc1a \ud835\udc1c\ud835\udc28\ud835\udc25\ud835\udc29\ud835\udc22\ud835\udc2b\ud835\udc1e \ud835\udc22 \ud835\udc1b\ud835\udc1e\ud835\udc2b\ud835\udc2c\ud835\udc1a\ud835\udc20\ud835\udc25\ud835\udc22, limitando gli effetti sui tessuti sani.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Si tratta di una terapia estremamente innovativa ed efficace: in base a allo studio DESTINY-Breast04 condotto su 557 pazienti, \ud835\udc21\ud835\udc1a \ud835\udc2b\ud835\udc22\ud835\udc1d\ud835\udc28\ud835\udc2d\ud835\udc2d\ud835\udc28 \ud835\udc1d\ud835\udc1e\ud835\udc25 \ud835\udfd3\ud835\udfce% \ud835\udc22\ud835\udc25 \ud835\udc2b\ud835\udc22\ud835\udc2c\ud835\udc1c\ud835\udc21\ud835\udc22\ud835\udc28 \ud835\udc1d\ud835\udc22 \ud835\udc29\ud835\udc2b\ud835\udc28\ud835\udc20\ud835\udc2b\ud835\udc1e\ud835\udc2c\ud835\udc2c\ud835\udc22\ud835\udc28\ud835\udc27\ud835\udc1e \ud835\udc2b\ud835\udc22\ud835\udc2c\ud835\udc29\ud835\udc1e\ud835\udc2d\ud835\udc2d\ud835\udc28 \ud835\udc1a\ud835\udc25\ud835\udc25\ud835\udc1a \ud835\udc1c\ud835\udc21\ud835\udc1e\ud835\udc26\ud835\udc22\ud835\udc28\ud835\udc2d\ud835\udc1e\ud835\udc2b\ud835\udc1a\ud835\udc29\ud835\udc22\ud835\udc1a \ud835\udc1e \ud835\udc1a\ud835\udc2e\ud835\udc26\ud835\udc1e\ud835\udc27\ud835\udc2d\ud835\udc1a\ud835\udc2d\ud835\udc28 \ud835\udc25\ud835\udc1a \ud835\udc2c\ud835\udc28\ud835\udc29\ud835\udc2b\ud835\udc1a\ud835\udc2f\ud835\udc2f\ud835\udc22\ud835\udc2f\ud835\udc1e\ud835\udc27\ud835\udc33\ud835\udc1a \ud835\udc20\ud835\udc25\ud835\udc28\ud835\udc1b\ud835\udc1a\ud835\udc25\ud835\udc1e.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">E&#8217; la prima volta che un simile trattamento viene utilizzato sia per i carcinomi Her2 sia Her2-low, che rappresentano circa il 50% delle diagnosi di tumore del seno.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud835\udc14\u0274 \u0262\u0280\u1d00\u0274\u1d05\u026a\ud835\udc2c\ud835\udc2c\u026a\u1d0d\u1d0f \u1d18\u1d00\ud835\udc2c\ud835\udc2c\u1d0f \u1d00\u1d20\u1d00\u0274\u1d1b\u026a \u1d18\u1d07\u0280 \u029f\u1d00 \ud835\udc2c\u1d04\u026a\u1d07\u0274\u1d22\u1d00 \u1d07 \u1d18\u1d07\u0280 \u029f\u1d00 \ud835\udc2a\u1d1c\u1d00\u029f\u026a\u1d1b\u00e0 \u1d05\u026a \u1d20\u026a\u1d1b\u1d00 \u1d05\u1d07\u029f\u029f\u1d07 \u1d18\u1d00\u1d22\u026a\u1d07\u0274\u1d1b\u026a<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud835\udc0b&#8217;\ud835\udc00\ud835\udc22\ud835\udc1f\ud835\udc1a, \ud835\udc00\ud835\udc20\ud835\udc1e\ud835\udc27\ud835\udc33\ud835\udc22\ud835\udc1a \ud835\udc08\ud835\udc2d\ud835\udc1a\ud835\udc25\ud835\udc22\ud835\udc1a\ud835\udc27\ud835\udc1a \ud835\udc1d\ud835\udc1e\ud835\udc25 \ud835\udc05\ud835\udc1a\ud835\udc2b\ud835\udc26\ud835\udc1a\ud835\udc1c\ud835\udc28, \ud835\udc21\ud835\udc1a \ud835\udc1d\ud835\udc1a\ud835\udc2d\ud835\udc28 \ud835\udc22\ud835\udc25 \ud835\udc2f\ud835\udc22\ud835\udc1a \ud835\udc25\ud835\udc22\ud835\udc1b\ud835\udc1e\ud835\udc2b\ud835\udc1a \ud835\udc1a\ud835\udc25\ud835\udc25\ud835\udc1a \ud835\udc2c\ud835\udc28\ud835\udc26\ud835\udc26\ud835\udc22\ud835\udc27\ud835\udc22\ud835\udc2c\ud835\udc2d\ud835\udc2b\ud835\udc1a\ud835\udc33\ud835\udc22\ud835\udc28\ud835\udc27\ud835\udc1e \ud835\udc1e \ud835\udc1a\ud835\udc25\ud835\udc25\ud835\udc1a \ud835\udc2b\ud835\udc22\ud835\udc26\ud835\udc1b\ud835\udc28\ud835\udc2b\ud835\udc2c\ud835\udc1a\ud835\udc1b\ud835\udc22\ud835\udc25\ud835\udc22\ud835\udc2d\u00e0 \ud835\udc1d\ud835\udc22 \ud835\udc2e\ud835\udc27 \ud835\udc27\ud835\udc2e\ud835\udc28\ud835\udc2f\ud835\udc28 \ud835\udc1f\ud835\udc1a\ud835\udc2b\ud835\udc26\ud835\udc1a\ud835\udc1c\ud835\udc28 per la seconda linea di trattamento (cio\u00e8 dopo una prima chemioterapia) del \ud835\udc2d\ud835\udc2e\ud835\udc26\ud835\udc28\ud835\udc2b\ud835\udc1e \ud835\udc1d\ud835\udc1e\ud835\udc25 \ud835\udc2c\ud835\udc1e\ud835\udc27\ud835\udc28 \ud835\udc26\ud835\udc1e\ud835\udc2d\ud835\udc1a\ud835\udc2c\ud835\udc2d\ud835\udc1a\ud835\udc2d\ud835\udc22\ud835\udc1c\ud835\udc28. Denominato trastuzumab-deruxtecan, questo farmaco chemioterapico agisce in combinazione con un anticorpo monoclonale: \ud835\udc22\ud835\udc27 \ud835\udc29\ud835\udc1a\ud835\udc2b\ud835\udc28\ud835\udc25\ud835\udc1e \ud835\udc26\ud835\udc28\ud835\udc25\ud835\udc2d\ud835\udc28 \ud835\udc2c\ud835\udc1e\ud835\udc26\ud835\udc29\ud835\udc25\ud835\udc22\ud835\udc1c\ud835\udc22, \ud835\udc2b\ud835\udc22\ud835\udc1e\ud835\udc2c\ud835\udc1c\ud835\udc1e \ud835\udc1a\ud835\udc1d \ud835\udc1a\ud835\udc2b\ud835\udc2b\ud835\udc22\ud835\udc2f\ud835\udc1a\ud835\udc2b\ud835\udc1e \ud835\udc1a\ud835\udc25\ud835\udc25\u2019\ud835\udc22\ud835\udc27\ud835\udc2d\ud835\udc1e\ud835\udc2b\ud835\udc27\ud835\udc28 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